Antarctic Mode Water

An estimate of Southern Ocean volume in temperature-salinity (T-S) classes is made with a focus on cold water masses south of the Polar Front, at depths shallower than 2,000 m. The volumetric diagram for waters below 5° C shows a deficit at temperatures near 0° C and 34.2 psu, surrounded by a ring of larger volumes, related to water mass formation near the Polar Front and near the continental margins as well as mixing effects. The cold, fresh extreme of the Antarctic Intermediate Water T-S relation shows a volumetric maximum, apparently distinct from the interior T-S relationship. We identify this mode as Antarctic Mode Water with a volumetric maximum centered near 2.0° C and 33.9 psu. This maximum lies on a large-scale ridge of high volume representing the Antarctic Surface Water mixed layers south of the Polar Front, at the northern edge of the seasonal sea-ice cover. Additional maxima on the diagram near freezing temperatures seem to be related to processes operating on the slope and shelf, though the data coverage in these regions is much reduced. The origin of the Antarctic Mode Water is ultimately due to sea-ice melt, which systematically shifts the T-S relation of surface water to lower salinities, whereas its thickness and distribution is linked to circumpolar northward Ekman transport and the eddy fluxes of the Polar Front

Birth, life and death of a cyclonic eddy in the Southern Ocean

The ACC is a climatically relevant frontal structure of global importance that regularly develops instabilities which grow into meanders that eventually evolve into long-lived cyclonic eddies. These eddies exhibit sustain primary productivity that can last several months fuelled by local resupply of nutrients. During April-May 2015 we conducted an intensive field experiment in the Southern Ocean (SMILES) where we sampled and tracked an ACC meander as it developed into an eddy and later vanished some 90 days later. The meander and later eddy physical characteristics were observed with a combination of high resolution hydrography, ADCP and turbulence observations in addition to surface and depth resolved biogeochemical observations of nutrients and phytoplankton. The life and death of the eddy was subsequently tracked through ARGO, BIO-ARGO and remote sensing

The Southern Ocean Observing System (SOOS)

[in “State of the Climate in 2014” : Special Supplement to the Bulletin of the American Meteorological Society Vol. 96, No. 7, July 2015

On the multiple Borsuk numbers of sets

The Borsuk number of a set S of diameter d >0 in Euclidean n-space is the smallest value of m such that S can be partitioned into m sets of diameters less than d. Our aim is to generalize this notion in the following way: The k-fold Borsuk number of such a set S is the smallest value of m such that there is a k-fold cover of S with m sets of diameters less than d. In this paper we characterize the k-fold Borsuk numbers of sets in the Euclidean plane, give bounds for those of centrally symmetric sets, smooth bodies and convex bodies of constant width, and examine them for finite point sets in the Euclidean 3-space.Comment: 16 pages, 3 figure

Towards the clinical implementation of pharmacogenetics in bipolar disorder.

BackgroundBipolar disorder (BD) is a psychiatric illness defined by pathological alterations between the mood states of mania and depression, causing disability, imposing healthcare costs and elevating the risk of suicide. Although effective treatments for BD exist, variability in outcomes leads to a large number of treatment failures, typically followed by a trial and error process of medication switches that can take years. Pharmacogenetic testing (PGT), by tailoring drug choice to an individual, may personalize and expedite treatment so as to identify more rapidly medications well suited to individual BD patients.DiscussionA number of associations have been made in BD between medication response phenotypes and specific genetic markers. However, to date clinical adoption of PGT has been limited, often citing questions that must be answered before it can be widely utilized. These include: What are the requirements of supporting evidence? How large is a clinically relevant effect? What degree of specificity and sensitivity are required? Does a given marker influence decision making and have clinical utility? In many cases, the answers to these questions remain unknown, and ultimately, the question of whether PGT is valid and useful must be determined empirically. Towards this aim, we have reviewed the literature and selected drug-genotype associations with the strongest evidence for utility in BD.SummaryBased upon these findings, we propose a preliminary panel for use in PGT, and a method by which the results of a PGT panel can be integrated for clinical interpretation. Finally, we argue that based on the sufficiency of accumulated evidence, PGT implementation studies are now warranted. We propose and discuss the design for a randomized clinical trial to test the use of PGT in the treatment of BD

Repetitive N-WASP–Binding Elements of the Enterohemorrhagic Escherichia coli Effector EspFU Synergistically Activate Actin Assembly

Enterohemorrhagic Escherichia coli (EHEC) generate F-actin–rich adhesion pedestals by delivering effector proteins into mammalian cells. These effectors include the translocated receptor Tir, along with EspFU, a protein that associates indirectly with Tir and contains multiple peptide repeats that stimulate actin polymerization. In vitro, the EspFU repeat region is capable of binding and activating recombinant derivatives of N-WASP, a host actin nucleation-promoting factor. In spite of the identification of these important bacterial and host factors, the underlying mechanisms of how EHEC so potently exploits the native actin assembly machinery have not been clearly defined. Here we show that Tir and EspFU are sufficient for actin pedestal formation in cultured cells. Experimental clustering of Tir-EspFU fusion proteins indicates that the central role of the cytoplasmic portion of Tir is to promote clustering of the repeat region of EspFU. Whereas clustering of a single EspFU repeat is sufficient to bind N-WASP and generate pedestals on cultured cells, multi-repeat EspFU derivatives promote actin assembly more efficiently. Moreover, the EspFU repeats activate a protein complex containing N-WASP and the actin-binding protein WIP in a synergistic fashion in vitro, further suggesting that the repeats cooperate to stimulate actin polymerization in vivo. One explanation for repeat synergy is that simultaneous engagement of multiple N-WASP molecules can enhance its ability to interact with the actin nucleating Arp2/3 complex. These findings define the minimal set of bacterial effectors required for pedestal formation and the elements within those effectors that contribute to actin assembly via N-WASP-Arp2/3–mediated signaling pathways

Valuations on lattice polytopes

This survey is on classification results for valuations defined on lattice polytopes that intertwine the special linear group over the integers. The basic real valued valuations, the coefficients of the Ehrhart polynomial, are introduced and their characterization by Betke and Kneser is discussed. More recent results include classification theorems for vector and convex body valued valuations. © Springer International Publishing AG 2017